October 2, 2023


Epicurean Science & Tech

Life sciences firm GeniPhys Inc. gets $974,349 NSF SBIR Section II grant

4 min read

WEST LAFAYETTE, Ind. — GeniPhys Inc., a daily life sciences organization concentrated on creating and commercializing a proprietary biopolymer engineering produced in Purdue University professor Sherry Harbin‘s laboratory, has been awarded a two-yr, $974,349 Modest Organization Innovation Investigation (SBIR) grant from the National Science Foundation. 

The main technology, known as Collymer, is a novel polymerizable collagen molecule that can be utilised to customized-style and design and fabricate implantable materials to address unmet purposeful tissue restoration and reconstruction demands, which includes breast tissue, skeletal muscle mass, cartilage, pores and skin, voice box and far more. This Stage II grant will be utilised to progress the commercialization of the firm’s initial product, Collymer Self Assembling Scaffold (Collymer SAS).

Collymer products harness both of those the mechanical and biochemical signaling functions of purely natural collagen uncovered inside of tissues. This will allow the materials to support regenerative and restorative therapeutic devoid of speedily degrading and eliciting irritation or international overall body responses. This mechanism of action has been validated in multiple preclinical proof-of-principle scientific studies. Furthermore, Collymer is very customizable, allowing for the generation of materials with a selection of formats and mechanical properties.

CEO Andy Eibling (remaining), Chief Scientific Officer Sherry Harbin and Product or service Advancement Manager TJ Puls of GeniPhys. (Purdue Analysis Foundation/Vincent Walter)
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GeniPhys was beforehand awarded a $225,000 NSF SBIR Stage I grant to complete preclinical tests to assess Collymer SAS prototypes for breast tissue restoration in a porcine lumpectomy model. Doing work collaboratively with associates of Purdue’s Weldon University of Biomedical Engineering, Purdue’s College or university of Veterinary Medicine and Indiana College University of Medication, all job milestones were reached. In addition, a peer-reviewed publication in the February 2021 challenge of Scientific Reviews resulted from this Period I venture, showcasing the translational potential of Collymer SAS as an effortless-to-use smooth tissue filler that conforms to individual-specific defects and regenerates complicated delicate tissues in the absence of swelling.

“We are honored to be selected for this grant and are energized to be capable to advance Collymer SAS toward submission to the U.S. Foods and Drug Administration and more commercialization,” GeniPhys CEO Andy Eibling said. “We believe the Collymer system will have a large effect for sufferers globally, and this grant is an important phase in the process.”

Harbin, founder and chief scientific officer of GeniPhys, is a professor in Purdue’s Weldon Faculty of Biomedical Engineering with a joint appointment in the Division of Standard Health care Sciences in Purdue’s College or university of Veterinary Drugs.

“Purdue has a extended, effective keep track of report of acquiring and translating ground breaking biomaterials focusing on tissue regeneration,” Harbin said. “This upcoming-generation engineering provides a biopolymeric material that can be broadly personalized and harnesses the body’s ability for regenerative healing by keeping inflammation and immune mediators at bay.”

TJ Puls, who properly trained underneath Harbin, now serves as product or service advancement manager for GeniPhys and the principal investigator for the SBIR Stage II award.

“This grant will make it possible for GeniPhys to scale up manufacturing abilities for commercialization and to file important regulatory submissions,” Puls explained.

GeniPhys will initially pursue regulatory filings for administration and restoration of wounds and defects that have an impact on the pores and skin as well as other tender tissues, which includes breast, skeletal muscle and adipose tissue. The organization will examine the use of Collymer materials in added programs leveraging strategic partnerships with progressive, business-main companies.

About GeniPhys Inc.

GeniPhys is a preclinical-stage medical know-how corporation located in Zionsville, Indiana, focused on empowering tissue regeneration and restoration. The firm’s Collymer technology is based on investigation carried out in Sherry Harbin’s lab at Purdue College. Resources geared up from the proprietary collagen polymer advertise tissue integration and technology while averting inflammation, fibrosis and scarring. The producing course of action of Collymer permits the fabrication of a number of implantable materials formats and has shown the capacity to produce pharmaceutical and mobile-based mostly therapies. 

About the NSF’s Compact Business enterprise Courses

America’s Seed Fund, driven by the NSF, awards $200 million per year to startups and tiny companies, reworking scientific discovery into products and solutions and solutions with commercial and societal influence. Startups working across almost all areas of science and engineering can obtain up to $2 million to support analysis and growth, supporting de-risk know-how for professional achievement. America’s Seed Fund is congressionally mandated via the Tiny Enterprise Innovation Exploration software. The NSF is an independent federal company with a spending budget of about $8.5 billion that supports elementary research and education throughout all fields of science and engineering. For much more information and facts, take a look at seedfund.nsf.gov.

Purdue Analysis Basis speak to: Steve Martin, [email protected]

Resources: Andy Eibling, [email protected]

Sherry Harbin, [email protected]

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